Giuseppe is an Associate Professor in Digital Innovation and High-Performance Computing in the School of Computing and Information Systems at the University of Melbourne.

He is an expert in interdisciplinary and translational research at the nexus of high-performance computing, artificial intelligence, and digital chemistry.

Giuseppe has led multi-institutional collaborations involving top Australian and US universities, supercomputing centers, and IT companies. 

From 2018 to 2023, he spearheaded Australia's contribution to the US Department of Energy's Exascale Computing Project (ECP), specifically GAMESS ECP. This initiative aimed to develop advanced computational chemistry software for the first exascale supercomputers Frontier and Aurora. It brought together notable institutions and companies such as ANU, Ames National Lab, Georgia Tech, Oak Ridge and Argonne National Labs, NVIDIA, Intel, AMD, and Cray. This was the only ECP project involving Australia.

Currently, he is the principal investigator of a Pawsey Centre for Extreme-scale Readiness (PaCER) project, aiming to advance Australia's capabilities in high-performance molecular modelling. The project partners include the Pawsey Supercomputing Centre, Iowa State University, Argonne National Lab, and several Australian universities.

From 2020 to 2022, Giuseppe’s team developed HPC algorithms that, using over 27,000 GPUs on the Summit supercomputer, broke (3 times) the world record for the largest computational quantum chemical modelling of matter. This showed the software’s potential to fast-track novel materials, catalysts, and drug development, gaining attention through multiple press releases, including on HPC wire.

In 2023, Giuseppe's pioneering research led to the creation of QDX Technologies, a deep-tech firm specializing in drug discovery. QDX leverages high-performance quantum chemistry and AI software to achieve unprecedented accuracy in the virtual screening and design of novel therapeutics. With its operations spanning Singapore, Melbourne, and Canberra, QDX Technologies is on a rapid growth trajectory, exemplifying the tangible impact of Giuseppe's scholarly work.

Giuseppe was nominated as one of Australia's Top 250 Researchers for 2024 by The Australian for high-quality research in top journals and significant impact measured by 5-year citation count.